Alfa Laval Heat exchanger close up

Alfa Laval Pharma-line Pharmaceutical Heat Exchanger

Euroflow GmbH Alfa Laval Master Distributor in central and southern Germany

Alfa Laval Pharma-line Pharmaceutical Heat Exchanger

Alfa Laval Pharma-line Pharmaceutical Heat Exchanger

The Alfa Laval Pharma-line is a pharmaceutical heat exchanger designed for Water For Injection and Purified Water systems. Manufactured in Sweden, these double tube sheet units maintain separation between product and utility media to prevent cross-contamination. This series provides a solution for facilities requiring documented safety and alignment with global hygienic requirements. The shell-and-tube design facilitates WFI cooling while supporting full drainability. Each unit is built to address the specific sanitation needs of high-purity water distribution.

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Documentation

Double tube sheet safety for pharmaceutical heat exchanger applications

The Pharma-line series establishes a secure barrier against contamination through its double tube sheet design. The service medium is sealed in the shell by the first tube sheet, while the second tube sheet seals the product within the tubes. This physical separation ensures that any joint leakage is visually detectable between the sheets before fluid mixing occurs. All product wetted parts are manufactured from SS316L seamless tubes, featuring a surface finish of Ra < 0.5 µm for mechanical polishing or Ra < 0.4 µm for electropolishing. These smooth surfaces are intended to prevent biofilm accumulation.

WFI cooling with the Pharma-line Point of Use module

The Pharma-line Point of Use is a plug-and-play module for subloop cooling in hot pharmaceutical water systems. This unit remains sanitized during standby mode by utilizing a pitot tube arrangement. Hot water from the main loop enters the cooler and circulates continuously, and a Reynolds number greater than 4000 is maintained when main-line velocity exceeds 1 m/s. This turbulent flow maintains self-sanitization. When cooling is active, the module provides cold water within seconds, which limits hold-up volume and reduces water waste. The design features zero dead legs and no internal welds to support high-purity distribution.

Mechanical integrity and installation flexibility

Pharma-line units are designed in accordance with ASME BPE, USP, and cGMP. Flexible legs permit mounting on the floor, wall, or ceiling. Horizontal installations require a slope of between 1% and 5% to ensure the tube side remains fully drainable. If the unit is positioned vertically for full drainability, it should be installed with tube side connections downwards. Each unit is pressure tested before shipment and is compatible with steam sterilization cycles, supporting operational uptime in production environments.

Technical Details

  • Product wetted steel parts: SS316L, seamless tubes
  • Shell side material: SS304L
  • Surface finish: Ra < 0.5 µm MP or Ra < 0.4 µm EP
  • Gaskets: PTFE, FDA compliant and USP Class VI certified
  • Design temperature: -10 °C to 200 °C (Pharma-line S); -19 °C to 200 °C (Pharma-line P)
  • Design pressure: FV / 10 barg or 15 barg
  • Vessel codes: PED, ASME, TSG
  • Welding standards: SS-EN ISO 15614-1, SS-EN287-1, SS-EN 1418, ASME IX
  • Point of Use flow capacity: up to 1200 L/h
  • Point of Use design temperature: 140 °C
  • Point of Use design pressure: 10 barg; 6 barg if pneumatic valve
  • Point of Use heat transfer area: 0.3–0.7 m²
  • Point of Use models: PoU200, PoU300, PoU400
  • Pharma-line S heat transfer area: 0.1–8.5 m²

Options and Configurations

  • Pharma-line S: Standard range with legs for flexible floor, wall, or ceiling mounting
  • Pharma-line P: Extended size range with ASME VIII U-stamp available as an option
  • Pharma-line Point of Use: Compact heat exchanger module for subloop WFI and PW cooling
  • Point of Use standard sizes: PoU200, PoU300, and PoU400
  • Pitot tube arrangement: Available to ASME BPE, ISO2037, and ISO1127 standards; options include isolation valves, return bend, and extension tubes
  • Point of Use valves: Manual or pneumatic configurations
  • Standard insulation: 30 mm mineral wool (ASTM C795) with SS304 sheathing
  • Removable tube bundle: Available on Pharma-line P on request
  • Documentation: Full Alfa Laval Q-doc package for supply chain transparency
  • Compliance: ASME BPE, USP Class VI, FDA, cGMP
  • Motor specifications not available for this product.

Pharmaceutical

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Biotechnology
Alfa Laval Prozesstechnik Edelstahl-Rohrleitungssystem und Wärmetauscher

Industries

The Alfa Laval Pharma-line pharmaceutical heat exchanger is used in pharmaceutical manufacturing and biotechnology sectors for high-purity water distribution. These units manage the temperature of Water For Injection and Purified Water in systems where hygienic integrity and regulatory compliance are critical. Facilities across pharmaceutical production and biotechnology rely on these heat exchangers to meet documented standards for sterile processing.

Advanced Sensing and Control for Process Optimisation

Integrating Alfa Laval ThinkTop V50 and V70 units into your valve clusters delivers maximum uptime and significant resource savings. Their 360° LED status indication gives operators real-time flow path monitoring from any angle.

  • Resource savings: Pulse and Burst SeatClean reduce CIP fluid consumption by up to 95%.
  • Fast setup: Auto-Setup and Live-Setup cut commissioning time by up to 90%.
  • Durable: IP69K rated, -10°C to +60°C, Nylon PA12 and 1.4301 stainless steel.
  • Easy integration: Supports 24VDC PNP, AS-Interface, and IO-Link. MTTF of 224 years.
  • Universal fit: Directly interchangeable with ThinkTop Classic; fits all Alfa Laval hygienic actuators.

Ready to optimise your CIP return and process flows?

Our products
Alfa Laval Sensing and Control Think Top V50 and V70
Marcus Schmidt, Euroflow GmbH owner

Are you interested?

As an Alfa Laval Master Distributor in Southern Germany, Euroflow GmbH delivers premium components and expert solutions for the dairy, brewing, beverage, food, cosmetics and pharmaceutical industries. Operating across postal codes 66-99 and 07-08, we serve Baden-Württemberg, Bavaria, Saarland, Rhineland-Palatinate, Hesse, Thuringia and Saxony with dedicated technical expertise.

As your competent partner for system integration, tank construction and end-user solutions, we provide comprehensive support in selecting optimal equipment for viscous product handling and cleaning processes. Our focus on pumps, valves, heat exchangers and tank equipment ensures reliable process performance.

Contact us today for a personalised quote and discover how our technical expertise can optimise your operations.

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FAQ

Euroflow serves customers across southern and central Germany — covering postal code areas 66–99 and 07–08, spanning Baden-Württemberg, Bavaria, Saarland, Rhineland-Palatinate, Hesse, Thuringia, and Saxony. As an Alfa Laval Master Distributor for tank manufacturers, plant engineers, system suppliers, and end customers, we provide expert support in selecting and designing systems for viscous product handling and cleaning applications.

The double tube sheet creates a physical gap between the service medium in the shell and the product in the tubes. If a leak occurs at either tube sheet joint, the fluid exits between the sheets for visual detection rather than mixing with the process media.

Regular inspection of the interior and exterior surfaces is necessary to maintain thermal performance. Gaskets must be replaced whenever the front cover is loosened, and bolts must be retightened in a diametrically staggered pattern progressing through four torque steps to a final torque of 70 Nm.

In standby mode, a pitot tube arrangement allows hot WFI from the main loop to circulate continuously through the Point of Use cooler and back. Maintaining a main line velocity above 1.0 m/s ensures the Reynolds number exceeds 4000, producing turbulent flow that keeps the module self-sanitizing without stagnant water.

Any questions?

If we still haven't answered your questions, you can contact us below and we will get back to you as soon as possible.

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+49 721 / 470 518 – 10

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 info@euroflow.de